ATOPICA CATS 100 MG/ML SOL 17 ML | CHRONIC ALLERGIC DERMATITIS

Treatment of chronic allergic dermatitis in cats

Atopica®, developed by Novartis Animal Health, is an innovative antipruritic and anti-inflammatory specially formulated to relieve the signs of chronic allergic dermatitis in cats. This medicine, based on cyclosporine, offers effective control of skin allergies, significantly improving the quality of life of affected pets.

Key Features

• High efficiency: Proven reduction of symptoms such as itching, redness and skin lesions.
• Versatile administration: It can be mixed with food or administered directly into the mouth.
• Adaptability: Adjustable doses and frequency of administration adapted to clinical needs.

Active Composition

• Cyclosporine A: 100 mg/ml.
• Excipients:
  • Tocopherol (E307) 1.05 mg.
  • Anhydrous ethanol (E1510) 94.70 mg.
  • Propylene glycol (E1520) 94.70 mg.

Indications of use

Cats: Symptomatic treatment of chronic allergic dermatitis, an inflammatory condition affecting the skin that is usually caused by environmental or food allergies.

Contraindications

• Do not use in cats with:
  • Known hypersensitivity to cyclosporine or any of its excipients.
  • Active infections of FeLV o IVF.
  • History of malignant or progressive disorders.
• Vaccination: Avoid the use of live vaccines during and two weeks before or after treatment.

Pharmacological Properties

Cyclosporine is a selective immunomodulator that acts by inhibiting the activation of T lymphocytes, which are primarily responsible for allergic reactions. This mechanism:

• Reduces the production of inflammatory cytokines such as IL-2.
• Inhibits the activity of mast cells, eosinophils and keratinocytes, responsible for itching and skin lesions.
• Improves the skin's barrier function, reducing inflammation and itching.

Route of Administration

• Orally: Administer directly into the cat's mouth or mixed with food.

Dosage and Dosage

1. Initial dose:
   • 7 mg/kg of body weight (0.07 ml of solution per kg), administered daily.
2. Maintenance dose:
   • Once symptoms are controlled, reduce the frequency of administration to alternate days.
   • In controlled cases, space doses every 3 or 4 days.
3. Restarting treatment:
   • If symptoms reappear, resume daily administration.
   • Some cases may require consecutive cycles of treatment.

Side effects

In clinical studies with cats treated with cyclosporine:

• Very common: Vomiting and diarrhea (usually mild and transient).
• Frequent: Lethargy, anorexia, hypersalivation, weight loss, and lymphopenia. These effects usually resolve with discontinuation of treatment or dose adjustment.
• Rare: Prolonged immunosuppression or opportunistic infections in predisposed cats.

Note: In case of persistent side effects, consult your veterinarian.

Drug Interactions

• Increase the concentration of cyclosporine:
  • Ketoconazole and macrolides such as erythromycin.
• They reduce the effectiveness of cyclosporine:
  • Anticonvulsants and certain antibiotics such as trimethoprim/sulfadimidine.
• Additional possible risks:
  • Combination with aminoglycosides or trimethoprim may increase nephrotoxicity.
  • Avoid concomitant use with macrocyclic lactones in sensitive cats due to risk of CNS toxicity.

Special Precautions

1. Clinical monitoring:
   • Perform regular monitoring of electrolytes, liver and kidney function during treatment.
2. Product handling:
   • Wear gloves and avoid contact with the solution.
   • Pregnant women should avoid direct handling of the medication.
3. Pre-existing conditions:
   • Avoid in cats with renal or hepatic insufficiency or severe systemic diseases.

Conservation Mode

• Optimum temperature: Store between 20 ° C and 30 ° C.
• Notes:
  • At temperatures below 20 °C a gel may form, which is reversible upon heating to 30 °C.
  • Small sediments do not affect the efficacy or safety of the product.

Presentation

• Available bottles:
  • 5 ml y 17 ml with dispensing kit (extraction tube and 1 ml syringe).

FAQ

1. How long does it take for Atopica® to take effect?

Improvement is usually seen within first weeks of treatment.

2. Can I stop treatment once the symptoms disappear?

Yes, Atopica® can be discontinued when symptoms are under control. If they reappear, treatment should be restarted.

3. What should I do if my cat does not accept the medication with food?

Administer the solution directly into the cat's mouth using the syringe included in the kit.

4. Can I combine Atopica® with other medications?

Avoid combining with medications that affect liver metabolism, such as ketoconazole or erythromycin. Consult your veterinarian before combining treatments.

5. What should I do if I notice vomiting or diarrhea?

These symptoms are common at the beginning of treatment and usually disappear without the need to stop the medication. Consult your veterinarian if symptoms persist.

Key Benefits of Atopica for Cats

• Effective control of chronic skin allergies.
• Improves the quality of life of cats by reducing itching and skin lesions.
• Adjustable treatment to suit the needs of each pet.

Atopica® 100 mg/ml Oral Solution is the ideal solution to manage the symptoms of chronic allergic dermatitis in cats, providing them with long-lasting well-being. Consult your veterinarian to start treatment.