VETORYL 5 mg: Treatment for Hyperadrenocorticism in Dogs

VETORYL is an innovative medication formulated for the management of hyperadrenocorticism (Cushing's syndrome) in dogs. Its active ingredient, trilostane , is an anticorticosteroid that effectively regulates the excessive production of glucocorticoids in cases of pituitary or adrenal disease.

Main Features of VETORYL 5 mg

1. Pharmaceutical form: Oral capsules for easy and precise administration.
2. Active Composition:
   • Trilostane: 5mg.
   • Excipients: Titanium dioxide (E171), yellow and black iron oxides (E172).
3. Therapeutic Indications:
   • Treatment of hyperadrenocorticism originally pituitary o adrenal in dogs.
4. Therapeutic Action:
   • It blocks the excessive synthesis of glucocorticoids in the adrenal glands, helping to regulate the body's metabolic functions.

Indications and Use

Target Species :

• Dogs with confirmed diagnosis of hyperadrenocorticism.

Therapeutic Indications :

• Effective management of symptoms such as:
  • Excessive thirst and urination.
  • Weight gain.
  • Lethargy.
  • Changes in skin and coat.

Contraindications

1. Do not administer in:
   • dogs with primary liver disease o renal insufficiency.
   • Dogs of less than 3 kg of weight.
2. Use during pregnancy and lactation:
   • Contraindicated in pregnant or lactating dogs, and in animals intended for reproduction.

Dosage and Administration Route

Route of Administration:

• Oral, with food to optimize absorption.

Recommended Starting Dose:

• 2 mg / kg administered once daily.
• Dose adjustment according to clinical response and monitoring.

Dosage Guide:

• Combine capsule sizes to achieve proper dosage.
• If symptoms persist, consider dividing the daily dose into two administrations (morning and evening) or increasing it by up to 50%.

Recommendations for use:

• Do not open or divide the capsules..
• In cases of persistent or poorly controlled symptoms, adjust the dose under strict veterinary supervision.
• Some dogs may require higher doses than 10mg/kg/day.

Adverse reactions

Contact Us:

• Lethargy, vomiting, diarrhea and anorexia.

Uncommon:

• Iatrogenic hypoadrenocorticism syndrome:
  • Dizziness, diarrhea, vomiting, lethargy, and collapse (Addisonian crisis).
• In rare cases:
  • Adrenal necrosis.
  • Unmasking of subclinical renal dysfunction.
  • Triggering of arthritis by reduction of endogenous corticosteroids.

Exceptional Cases:

• Sudden death.

Note : If severe signs are observed, discontinue the medication and consult a veterinarian immediately.

Precautions and Monitoring

1. Accurate Diagnosis:
   • It is essential to confirm the diagnosis before starting treatment.
2. Clinical Follow-up:
   • Evaluate regularly electrolytes, u, creatinine y liver enzymes.
3. Special conditions:
   • In the presence of d and hyperadrenocorticism, monitor closely.
   • Dogs previously treated with mitotane should wait a month before starting Vetoryl.
   • Caution in dogs with preexisting anemia due to possible decrease in blood cell volume.
4. pancreatitis:
   • Hyperadrenocorticism increases the risk of pancreatitis, even during treatment.

Conservation Mode

• Temperature: Keep to less than 25 °C.
• Store in the original blister inside its packaging to protect from light.

Advantages of VETORYL®

1. Specialized Treatment:
   • Effective for the control of Cushing's syndrome in older dogs.
2. Precision in Dosage:
   • Adjustable presentations allow therapy to be adapted to each case.
3. Strict Monitoring:
   • Facilitates safe adjustments based on patient response.
4. Patient Wellbeing:
   • Improves quality of life by relieving symptoms associated with hyperadrenocorticism.

FAQ

1. What happens if a dose is missed?
   Take the missed dose as soon as possible, but do not double the next dose.
2. How long does it take to see improvement?
   Symptoms usually improve during the first few weeks of treatment.
3. Is continuous monitoring necessary?
   Yes, regular testing is essential to adjust dosage and prevent adverse effects.
4. Can it be combined with other medications?
   Consult your veterinarian, especially if the dog is receiving other treatments.

Presentation and Registration

• 5 mg capsules in blisters.
• Reg No.: Medication subject to veterinary prescription.

Vetoryl® is the gold standard treatment for canine hyperadrenocorticism. Consult your veterinarian to ensure proper management and improve your pet's quality of life.