TABERNIL SINGING 20 ML

To stimulate the beginning and development of singing.

ANNEX I
TECHNICAL SHEET (SUMMARY OF PRODUCT CHARACTERISTICS)
1. NAME OF THE VETERINARY MEDICINAL PRODUCT
TABERNIL SINGING
2. QUALITATIVE AND QUANTITATIVE COMPOSITION
Active principles
Methyltestosterone ………………………………. 0,3mg
Vitamin A ……………………………………. 2000 IU
Vitamin D3 ……………………………………….. 400 IU
Vitamin E ………………………………………. 2,5mg
Excipients:
Sodium methyl parahydroxybenzoate (E 219) 0,9 mg
Butylated hydroxyanisole (E 320)..………………………………0,2 mg
Propyl gallate (E 310)………………………………..1,0 mg
Excipients, csp ………………………………….. 1 ml
3. PHARMACEUTICAL FORM
Oral solution.
4. CLINICAL DATA
4.1. target species
Birds (ornamental birds – songbirds).
4.2. Indications for use for each of the target species
To stimulate the beginning and development of singing.
4.3. contraindications
They have not been described in the target species.
4.4. Special warnings for each target species
If the desired result is not obtained after 3 – 4 weeks of treatment, you should
reconsider the diagnosis, considering the possibility that the animal is
undergoing some other type of process.
When the cessation of singing is a consequence of states of stress, moulting,
infectious or parasitic processes, or any other disease, before
to administer TABERNIL CANTO it is necessary to solve the primary process.
Avoid treating young animals before the first molt or continued use in
adults, respecting the established treatment periods.
4.5. Special precautions for use, including any specific precautions that
should be taken by the person administering the medication to the animals.
– Special precautions for use:
During the treatment, the bird must be in an individual or competition cage.
For hygienic reasons, it is recommended to change the drinking water, medicated or not,
daily.
Daily water consumption depends on ambient temperature and other
factors such as the physiological state of the birds, so the actual amount of water
consumed can vary considerably.
– Specific precautions to be taken by the person administering the
medicine to animals:
They have not been described.
4.6. Adverse reactions (frequency and seriousness)
Use of the drug could lead to more aggressive behavior.

4.7. Use during pregnancy, lactation or lay
Not applicable.
4.8. Interactions with other drugs and other forms of interaction
They have not been described.
4.9. Dosage and route of administration
The week before starting the treatment it is recommended to establish the consumption
Approximate daily amount of water per day (in milliliters). An initial reference is a consumption
between 2-3 ml per bird per day.
Preparation of oral solutions for administration in drinking water:
For 20 ml of medicated water: Assuming the bird consumes 2-3 ml of water daily.
day, and you should receive between 3-4 drops, it is recommended to add 40 drops in 20 ml of water.
If the bird consumes another amount of water per day, calculate the number of drops per day.
add in the water according to the following formula:
Total volume (drinker capacity, ml) X 4 drops = drops to add to the
drinker with water
Individual daily average consumption (ml)
The administration should be carried out 2 – 3 times a week (every 48 or 72 hours).
In individual doses, 3-4 drops of the product per animal provide:

4.10. Overdose (symptoms, emergency procedures, antidotes)
It has not been described.
4.11. Waiting time
Not applicable.
5. PHARMACOLOGICAL PROPERTIES
ATC Vet Code: QG03EK
Group: Androgens and female sex hormones in combination with other
substances.
5.1. Pharmacodynamic properties
There are several nuclei of the brain involved in the singing system, among which
the Superior Vocal Center (CVS) and the Robustus Archistrialis (RA) and
those that are with learning in young animals: IMAN and area X.
has verified that the development, especially of the CVS, in periods
seasonal is linked to the increase in circulating testosterone levels, therefore
which its exogenous contribution in the precise periods, will favor a development
appropriate. The action of testosterone is exerted on the CVS, which is in charge of
issue the orders for the execution of the song. In spring when the levels of
testosterone are high, the CVS and the RA increase in size, for later
contract which coincides with low levels of circulating testosterone.
The contribution of vitamin A collaborates in the maintenance of the epithelia both
related to reproduction as related to the own vocal organ
of birds that is part of the respiratory system. The inclusion of vitamin A and
D3 is related to the possibility of lack of singing due to keratinization of
the epithelia, loss of appetite. On the other hand, vitamin E is important

physiology in the regulation of gonadal development and function, essential for
that the song manifests itself completely.
5.2. Pharmacokinetic properties
Methyltestosterone is a derivative of testosterone that unlike this
It presents a good absorption after its administration by oral vial. It is not metabolized
rapidly like it at the intestinal level nor is it inactivated at the hepatic level when
administered orally. After absorption, it passes into the blood where it is transported in
combination with plasma proteins.
Vitamin A is easily absorbed in the intestine, as it is a vitamin
Liposoluble said absorption is related to that of fats. absorption
intestine is also carried out through the lymphatics and then reaches the blood in the form of
esterified, which causes a concentration peak at 4 hours, to
decrease parallel to its storage in the liver, this storage
is facilitated by vitamin E. 95% of the vitamin A content in the
organism is found in the liver. Released from the liver into the circulation
usually in the form of retinol, circulating combined with the binding protein of the
retinol. The half-life of retinol (bound to the binding protein) is around 4
hours. The metabolization is carried out by two mechanisms: oxidation with
formation of retinoic acid that occurs mainly in the liver. With
degradation and formation of inactive metabolites that are excreted in the urine and
conjugation of retinol and retinoic acid with glucuronic acid.
Vitamin D is well absorbed in the intestine, requiring the presence of fatty acids.
bile As in the case of vitamin A, absorption through the lymphatics, passed to
general circulation and circulating combined with alpha globulin. binding protein
of vitamin D or transcalciferin that also transports its metabolites. Pass to
liver, where it accumulates mainly, as well as in adipose tissue. Also
It is stored in the kidney and spleen. Of all these organs it is freed to exercise its
functions. It has a long half-life due to its storage
(about 30 days) The half-life of its main metabolite, calcitriol, is
around 5 o'clock. Elimination is mainly through the bile.
intestine and scarcely in the urine.
Vitamin E is not very well absorbed in the intestine and an important part of the
ingested is recovered in feces without being absorbed (around 65%). his way of
Absorption is similar to that of other fat-soluble vitamins. After absorption for a
circulating blood after transformation into alpha-tocopherol. From blood to tissues
and is stored mainly in muscle, adipose tissue, and liver. is metabolized
and transforms by oxidation into tocopheronic acid which in turn transforms into the
glucuronic acid and the corresponding lactone. These metabolites are excreted in the
urine.
6. PHARMACOLOGICAL DATA
6.1. List of excipients
Butylated hydroxyanisole (E 320), Propylene glycol, Sodium methyl parahydroxybenzoate (E
219), Glycerol, Disodium Edetate, Propyl Gallate (E 310), Sinespum C,
Macrogolglycerol Hydroxystearate, Concentrated Hydrochloric Acid and Water
purified.
6.2. Main incompatibilities
They have not been described.

6.3. Shelf-life of the medicinal product, if necessary after reconstitution
of the medicine or when the packaging is first opened
packaging
Shelf-life of the medicinal product in closed immediate packaging: 2
years.
Shelf-life after first opening the immediate packaging:
28 days.
Shelf-life of the drug incorporated into drinking water: 24 hours.
6.4. Special storage precautions
The bottle must be kept tightly closed, in a cool place and protected from light.
6.5. Nature and composition of the primary packaging
The preparation is presented in bottles containing 20 ml, inside a case of
cardboard. National Code: 5732336
The bottles correspond to high-density polyethylene containers.
Each bottle is provided with a low-density polyethylene stopper/dropper,
closed with polypropylene screw cap.
6.6. Special precautions to be observed in disposing of the
Unused veterinary medicinal product or residues derived from its
utilization.
Any unused veterinary medicinal product or residues derived from it
must be disposed of in accordance with current regulations.
7. MARKETING AUTHORIZATION HOLDER
DIVASA-FARMAVIC, SA
Ctra. Sant Hipólit, km 71
08503 GURB-VIC (Barcelona)
Tel: 938860100
Fax: +938860131
ADDITIONAL INFORMATION

See technical sheet