NELIO GATO 2,5MG 100 TABLETS | For chronic kidney disease

NELIO

Angiotensin Converting Enzyme (ACE) Inhibitor Oral Tablet

Pharmaceutical form

Oral tablet (Comp.o.)

Composition by tablet:

Nelio 2,5 mg for Cats: Benazepril hydrochloride 2,5 mg.

Nelio 5 mg for Dogs: Benazepril hydrochloride 5 mg.

Nelio 20 mg for Dogs: Benazepril hydrochloride 20 mg.

Pharmacological properties

Benazepril hydrochloride is a prodrug hydrolyzed in vivo to its active metabolite, benazepril. Benazeprilat is a highly potent selective ACE inhibitor, thus preventing the conversion of inactive angiotensin I to active angiotensin II and thus also reducing aldosterone synthesis. Thus, it blocks the effects mediated by angiotensin II and aldosterone, including arterial and venous vasoconstriction, sodium and water retention by the kidneys, and remodeling effects (including pathologic cardiac hypertrophy and degenerative renal changes).

In dogs with congestive heart failure, it reduces blood pressure and the volume load of the heart.

In cats with renal insufficiency, it normalizes elevated glomerular capillary pressure and reduces systemic blood pressure. Reducing glomerular hypertension may slow the progression of kidney disease by inhibiting further damage to the kidneys.

Interactions and incompatibilities

In dogs with congestive heart failure, the drug has been administered in combination with digoxin, diuretics, pimobendan, and antiarrhythmic drugs without evidence of associated adverse reactions.

The concomitant use of NSAIDs or other drugs with a hypotensive effect should be considered with caution.

Monitor plasma potassium levels when the medicinal product is used in combination with a potassium-sparing diuretic due to the risk of hyperkalemia (high blood potassium level).

Indications

Dogs: Treatment of congestive heart failure.

Cats: Reduction of proteinuria associated with chronic kidney disease.

Contraindications

Hypersensitivity to the active substance or to any of the excipients.

Cases of hypotension, hypovolemia, hyponatremia or acute renal failure.

Cases of decreased cardiac output due to aortic or pulmonary stenosis.

Pregnancy and lactation: The safety of benazepril in these periods has not been established.

Adverse reactions

In animals with chronic kidney disease, a moderate increase in plasma creatinine concentrations may occur. This is probably due to the effect of the treatment in reducing blood pressure in the kidney and is therefore not necessarily a reason to discontinue treatment, unless the animal exhibits other adverse reactions.

In cats, food consumption and weight may be increased. Vomiting, anorexia, dehydration, lethargy, and diarrhea have occurred rarely.

Vomiting or fatigue may be observed in some dogs with congestive heart failure during treatment.

Route of administration

Orally.

The tablets are flavored and are willingly ingested by most dogs and cats.

Posology

Dogs: 0,25 0,5 mg benazepril hydrochloride/kg weight, once a day. In dogs with congestive heart failure the dose can be doubled.

Cats: 0,5-1,0 mg benazepril hydrochloride/kg body weight, once daily.

Special precautions

In the case of chronic kidney disease, the veterinarian will analyze the animal's hydration status before starting treatment and may recommend routine blood tests during treatment to monitor plasma creatinine concentration and blood red cell count.

Do not use during pregnancy and lactation. The safety of the drug in these periods has not been established.

The efficacy and safety of the drug in dogs and cats weighing less than 2,5 kg have not been established.

Pregnant women should avoid accidental oral exposure, as angiotensin-converting enzyme (ACE) inhibitors have been shown to affect the fetus during pregnancy in humans.

Wait time

Not applicable.

conservation mode

• Do not store at temperatures above 30 °C.
• Split tablets should be kept in the opened blister pack.

Comments

With veterinary prescription.

TECHNICAL SHEET

NELIO