ADVOCIN-180 100ML

ADVOCATION 180
Anti-infective in injectable solution

Laboratory
PFIZER, SA
Pharmaceutical form
Injectable solution (Sol.i.)
Composition per ml:
Danofloxacin (as mesylate) 180,00 mg.
Pharmacological properties
Danofloxacin is a synthetic antimicrobial agent from the group of fluoroquinolones. Activity
The antimicrobial activity of danofloxacin is based on the inhibition of microbial DNA gyrase and the
topoisomerase IV. The inhibitory effect is found in the second phase of the enzymatic process, when
separate the functions of breaking and melting. Produces a stable complex between the enzyme and DNA. He
The result is the interruption of DNA replication and transcription.
Interactions and incompatibilities
None known.
Indications and target species
Cattle: Treatment of bovine respiratory disease caused by Mannheimia haemolytica,
Pasteurella multocida and Histophilus somni sensitive to danofloxacin. mastitis treatment
acute bovine disease caused by Escherichia coli, sensitive to danofloxacin.
Neonatal calves: Treatment of enteric infections caused by susceptible Escherichia coli
to danofloxacin.
Contraindications
Do not use in case of known hypersensitivity to the active ingredients, to other (fluoro)quinolones
or to any ingredient of the product.
efectos secundarios
• In very rare cases, immediate anaphylactic shock may occur in sensitive animals or
delayed after injection.
• Subcutaneous injection of the product causes a moderate inflammatory response in the tissue.
surrounding the injection site. The resulting injuries can last up to 30 days.
Route of administration
Subcutaneous or intravenous.
Posology
6 mg/kg body weight (1 ml/30 kg body weight) as a single injection subcutaneously or
intravenous. If clinical signs of respiratory or enteric disease persist after 48 hours,
You can administer a second dose.
• It is recommended to treat animals at the first signs of disease and evaluate their response to
treatment at 48 hours.
Special precautions
• The use of fluoroquinolones should be based on susceptibility testing and taking into account the
official and local regulations for the use of antimicrobials.
• Overdosing at multiple doses than the recommended one induces erosion of articular cartilage.
Caution should be exercised in adjusting the dose and the product should be used with caution in
animals with joint disease or growth plate disorders.
• Wash hands after use. In case of contact with skin, wash with soap and water
immediately. Do not eat, drink or smoke during administration.
• People with known hypersensitivity to quinolones should avoid any contact with
the product.
Wait time
Meat: 8 days.
Milk: 4 days.
conservation mode
Store in the original container in order to protect from light. Do not freeze.
Comments
With veterinary prescription.
Presentation
Containers of 50 and 100 ml.
Reg No.
1.421-ENG

See technical sheet