GANADEXIL ENROFLOXACIN 5% 100 ML | INJECTABLE ANTIBIOTIC

GANADEXIL ENROFLOXACIN 5%

Injectable solution
Antibacterial in injectable solution
Laboratory
VETERINARY INDUSTRIAL, SA – INVESA
Pharmaceutical form:
Injectable solution (Sol.i.)
Composition::
Enrofloxacin 50mg; benzyl alcohol 10 mg.
Pharmacological properties:
Enrofloxacin is an antibiotic that belongs to the chemical class of fluoroquinolones. He
compound exerts bactericidal activity through a mechanism of action based on the
inhibition of subunit A of bacterial DNA gyrase (Topoisomerase II), preventing rotation
negative axial of the DNA molecule.
Enrofloxacin exerts its antimicrobial action at low concentrations, compared to most of the
Gram (-) and many Gram ( ) bacteria, both aerobic and anaerobic.
Antibacterial spectrum: Staphylococcus spp., Bordetella bronchiseptica, Escherichia coli,
Enterobacter spp., Proteus spp., Salmonella spp., Pseudomonas spp., Streptococcus spp., Pasteurella
spp., Mycoplasma spp., Enterococcus spp., Actinobacillus pleuropneumoniae. Gram enteric bacilli
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Enrofloxacin has relatively high IM and SC bioavailability in almost all species.
studied.
In cattle, after IM administration of 5 mg/kg, a maximum concentration of 1 mg/ml is observed.
that lasts for more than 6 h. The volume of distribution is equal to 0,6 l/kg, the half-life of
plasma elimination is equal to 2 h. and clearance equal to 210 ml/kg/h.
Interactions and incompatibilities:
• In dogs and cats, antagonistic effects may occur in joint administration with
chloramphenicol, macrolides or tetracyclines.
• In dogs, do not use simultaneously with theophylline.
• Do not apply simultaneously with non-steroidal anti-inflammatory drugs (may cause
seizures).
• Hepatic interactions may appear with other hepatic elimination drugs.
Indications and target species:
Cattle (Calves):
• Respiratory tract infections: bronchopneumonia, pasteurellosis and mycoplasmosis.
• Gastrointestinal tract infections: Diarrhea caused by colibacillus, colibacillosis and
colisepticemia.
Pigs: Treatment of piglet diarrhea, diarrhea and enterotoxemia caused by E. coli
and Salmonella spp. and MMA syndrome.
Dogs: Treatment of infections of the respiratory and digestive organs, of the urinary system and
of the skin produced by microorganisms sensitive to enrofloxacin.
• The use of this product must be restricted to those cases in which bacteria are shown
resistant to other antibiotics; a bacteriological confirmation of the
diagnosis and a sensitivity test of the bacteria causing the process.
• If there is no improvement within three days of starting therapy, a treatment may be indicated.
change in chosen therapy.
Contraindications:
• Animals with cartilage growth disorders should not be treated.
• Exclude from treatment dogs and cats under 12 months of age in small breeds and
medium, and 18 months in large breeds, or that have not finished their growth phase.
• Dogs with a clinical history of epilepsy and nervous disorders will also be excluded.
related to GABA.
Side effects:
No secondary effects derived from the administration of the specialty have been recorded in the
target species for which it is indicated. However, like other fluoroquinolones,
enrofloxacin has a damaging action on the joints, especially in young animals. In
Consequently, care must be taken to ensure that the administration of enrofloxacin is adequate, without
increase the dose or treatment time excessively.
• In dogs and calves, gastrointestinal disorders may occasionally occur.
• After administration, the specialty can produce an irritant effect at the point of
injection, although it disappears spontaneously after 4-5 days.
Route of administration:
Intramuscular or subcutaneous.
Posology:
Cattle (Calves): 0,5-1 ml (equivalent to 25-50 mg of enrofloxacin)/10 kg of bw every day
for 3 days. Continue treatment for up to 5 days in the case of salmonellosis or severe infections.
subcutaneous route. Do not apply more than 10 ml at the same injection site.
Pigs: 0,5-1 ml (equivalent to 25-50 mg of enrofloxacin)/10 kg of bw every day for 3 days.
Continue treatment for up to 5 days in the case of salmonellosis or severe infections. Via
intramuscular. Do not apply more than 2,5 ml at the same injection site.
Dogs: 0,1 ml (equivalent to 5 mg of enrofloxacin)/kg of bw every day for 5 days. Via
subcutaneous If no clinical improvement is observed in 3 days, reconsider the treatment.
• To ensure a correct dosage, the weight of the animals must be determined.
Wait time:
Meat: 14 days.
Conservation mode:
Keep at a temperature below 25 °C and protected from light.
Remarks:
Dispensation with veterinary prescription.
Presentation:
100 ml and 250 ml containers.
Reg No.:
0944 ESP

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