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CLAVASEPTIN 250MG 100 COMPRIMIDOS | ANTIBIOTICO PARA PERROS
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CLAVASEPTIN 250mg for Canine Periodontal Infections

Combines amoxicillin and clavulanic acid for broad spectrum antibacterial action.

★★★★★ 4.23 (56 reviews)
E291.69
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CLAVASEPTIN treats or aids in treating periodontal infections in dogs caused by bacteria sensitive to amoxicillin in combination with clavulanic acid. The active ingredients are amoxicillin (200 mg per tablet) and clavulanic acid (50 mg per tablet). Amoxicillin is an aminobenzylpenicillin that prevents bacterial cell wall formation by interfering with peptidoglycan synthesis. Clavulanic acid is an irreversible inhibitor of beta lactamases, protecting amoxicillin from inactivation.

Pharmacodynamic data from European isolates (2002) show the following MIC90 values for amoxicillin/clavulanic acid (2:1 ratio): Streptococcus spp. 0.4/0.2 µg/ml, Pasteurellaceae 0.4/0.2 µg/ml, Escherichia coli 5.3/2.6 µg/ml, Enterobacteriaceae 22.6/11.3 µg/ml (except Enterobacter spp.), Pseudomonadaceae 147.0/73.5 µg/ml, and Enterobacter spp. 49.6/24.8 µg/ml. Resistance is mainly mediated by beta lactamases, particularly in Pseudomonadaceae (81.25%) and Enterobacter spp. (55.5%).

Pharmacokinetically, after oral administration at the recommended dose in dogs, absorption is rapid. Peak plasma concentration for amoxicillin is 8.5 µg/ml reached at 1.4 hours, and for clavulanic acid is 0.9 µg/ml reached at 0.9 hours. Elimination is also rapid. No accumulation occurs with repeated dosing, and steady state is reached after the first administration.

Active Ingredients

Each tablet contains amoxicillin (as trihydrate) 200 mg, clavulanic acid (as potassium salt) 50 mg, and iron oxide brown (E 172) 0.475 mg.

Indications

For dogs: treatment or adjunctive treatment of periodontal infections caused by bacteria sensitive to amoxicillin in combination with clavulanic acid.

Dosing Guide

Follow your veterinarian's prescription.

Storage

Store as directed on packaging.

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