Advocate Spot On for Dogs 25-40 kg: Flea, Worm & Mite Treatment

Advocate is a broad-spectrum antiparasitic spot-on solution for dogs. It treats and prevents infestations by fleas (Ctenocephalides felis), ear mites (Otodectes cynotis), and circulating microfilariae (Dirofilaria immitis). It also prevents heartworm (L3/L4 larvae), subcutaneous dirofilariosis (Dirofilaria repens L3), spirocercosis (Spirocerca lupi), and angiostrongylosis (Angiostrongylus vasorum L4 and immature adults). It reduces circulating microfilariae of Dirofilaria repens and treats gastrointestinal nematodes (Toxocara canis, Ancylostoma caninum, Uncinaria stenocephala, Toxascaris leonina, Trichuris vulpis), chewing lice (Trichodectes canis), sarcoptic mange (Sarcoptes scabiei), demodicosis (Demodex canis), and infections by Angiostrongylus vasorum and Crenosoma vulpis. It also provides strategic treatment of flea allergy dermatitis (FAD).

Imidacloprid, a chloronicotinyl ectoparasiticide, is effective against flea larvae and adults. It distributes rapidly over the dog's skin within the first day of application. Moxidectin, a milbemycin macrocyclic lactone, is active against many internal and external parasites, including Dirofilaria immitis larvae (L3, L4) and gastrointestinal nematodes. It is absorbed through the skin and reaches peak plasma concentrations in 4 to 9 days in dogs, then is eliminated slowly from plasma.

Advocate may cause transient pruritus. Rarely, greasy hair, erythema, vomiting, or local hypersensitivity reactions may occur, resolving without treatment. If the animal licks the application site, transient neurological signs may rarely be observed. The product has a bitter taste.